منابع مشابه
Studies on the Antihypertensive Effect of Abana in Rats
Treatment with Abana (3 g/kg/day, p.o) for 3 weeks, reduced the blood pressure of unilaterally nephrectomized DOCAsalt-treated hypertensive rats. Similar reduction in blood pressure was also observed in the CdCh (1 mg/kg/day, i.p. for two weeks) treated hypertensive rats. The pressor response to adrenaline and noradrenaline (1 and 2 μg/kg) was reduced by chronic administration of Abana in these...
متن کاملkiDney Diseases
Introduction. We assessed whether cosupplementation of vitamins C and E has additive beneficial effects on reducing the kidney damage and attenuation of the arterial pressure elevation compared to administration of either vitamin C or vitamin E alone in deoxycorticosterone acetate-salt-induced hypertension. Materials and Methods. Forty rats were divided into 4 study groups and 1 sham-operated g...
متن کاملTNF- inhibition reduces renal injury in DOCA-salt hypertensive rats
Elmarakby AA, Quigley JE, Imig JD, Pollock JS, Pollock DM. TNFinhibition reduces renal injury in DOCA-salt hypertensive rats. Am J Physiol Regul Integr Comp Physiol 294: R76–R83, 2008. First published November 7, 2007; doi:10.1152/ajpregu.00466.2007.—Studies suggest that the inflammatory cytokine TNFplays a role in the prognosis of end-stage renal diseases. We previously showed that TNFinhibiti...
متن کاملEffect of Central Losartan on DOCA-Salt Hypertension Rats
Background: The purpose of this study was to investigate whether brain AT1 receptor stimulation contributes as a hypertensive mechanism to deoxycorticosterone acetate (DOCA)-salt hypertension. Methods: 1) Acute injection: Losartan (1 mg/4 uL) or artificial cerebrospinal fluid (aCSF) was injected into the lateral cerebral ventricle (icv) of conscious control uninephrectomized Wistar rats or rats...
متن کاملBlood Pressure and Small Arteries in DOCA-Salt–Treated Genetically AVP-Deficient Rats
Hypertension is associated with structural and mechanical abnormalities of resistance arteries. We have recently reported that vasopressin may be involved in the blood pressure elevation and remodeling of resistance arteries in deoxycorticosterone acetate (DOCA)-salt hypertension, perhaps by modulating vascular endothelin-1 expression. We tested this hypothesis further by examining DOCA-salt hy...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Pharmacology
سال: 2019
ISSN: 0160-2446
DOI: 10.1097/fjc.0000000000000753